In another study, curcumin treatment was shown to sensitize CSC subpopulation to cisplatin chemotherapy by increasing expression of p21; CSC subpopulation in this study was double-positive (CD166+/EpCAM+) and highly migratory, derived from non-small cell lung cancer (NSCLC) cell lines (A549 and H2170) [137]. Here, CDKN1A is linked to non-small cell lung carcinoma.