GJA1 and glioma: On the other end, in glioma CSCs, it was found that down-regulation of Cx43 by hypermethylation of its promoter determined GJIC inhibition and that reconstitution of Cx43 inhibited CSC self-renewal, invasive capability, and tumorigenicity via a GJIC-independent manner through the regulation of the Wnt/catenin signaling pathway [112].