Chirality-sorted SWCNTs emitting at different wavelengths in the NIR were used to selectively track and deliver two therapeutic payloads in vitro: CCR5 siRNA and the small-molecule drug PX-866, targeting inflammation and fibrosis factors that mediate the translation of nonalcoholic steatohepatitis into hepatocellular carcinoma. Here, CCR5 is linked to hepatocellular carcinoma.