Further investigations revealed that elevated lipid peroxidation products such as lipid-derived ROS and Reactive Nitrogen Species (RNS) could be crucial in the HNSCC development [105,106,107], given that the antioxidant compound apigenin suppressed CDDP/5-fluorouracil (5-Fu) induced cytotoxicity via the Tumor Necrosis Factor (TNF)/Bcl-2 pathway [108]. The gene discussed is TNF; the disease is head and neck squamous cell carcinoma.