At the cellular level, a positive correlation between glutaminase and aldehyde dehydrogenase (ALDH) was reported, while the administration of glutamine could enhance the ALDH expression and restored the tumor growth in ALDHloCD44lo cells, suggesting that glutaminolysis-related manipulations could be a potential method for the development of a HNSCC stem cell based therapeutic regimen [141]. The gene discussed is GLS; the disease is head and neck squamous cell carcinoma.