IL6 and neoplasm: These CAFs express interleukin 6 (IL6), C-C motif chemokine 2 (CCL2), and Transforming Growth Factor Beta 3 (TGFB3) that induce the differentiation of peripheral blood mononuclear cell (PBMC) to MDSC, which contributes to T cell depletion in the tumor microenvironment [80,81].