CASP1 and neoplasm: Further, cytosolic DNA and DAMPS induce the activation and assembly of AIM2 and NLRP3 inflammasomes, respectively, which canonically leads to caspase-1-mediated maturation and the release of IL-1β and IL-18 through exocytosis or gasdermin-dependent pyroptosis [43] from tumor microenvironment components including tumor cells, stromal fibroblasts, TILs, and endothelial cells [44].