The recent Cancer Genome Atlas (TCGA) study, which analyzed the deletion rate according to the Genomic Identification of Significant Targets in Cancer (GISTIC), reported that 13% of LMS samples had a deep deletion (possibly homozygous) and 68% had a shallow deletion (possibly heterozygous) of the PTEN gene, while PTEN mutations were detected in 5% of tumor samples (Figure 2C) [14]. Here, PTEN is linked to cancer.