Thus, treatment with TRAIL induced clathrin-dependent endocytosis of TRAIL-R1 and/or TRAIL-R2 in BJAB Burkitt lymphoma B cells, HeLa human cervical carcinoma, A549 lung cancer, MDA-MB-231 breast cancer, and Huh-7 hepatocellular carcinoma cells [29,35,36,37]. Here, TNFRSF10A is linked to breast cancer.