BCL2 and neoplasm: Also, the combination treatment inhibited the canonical pathway in Wnt signaling by suppressing β-catenin expression and induced apoptosis in TNBC cells, in ER+ve cells, and in the tumor sample of the tumor-xenografted mice by suppressing Bcl-2 expression and by activating caspases3 that mediated PARP cleavage, ultimately leading to DNA condensation and fragmentation.