Another study reported PGLYRP2−/− and NOD2−/− double knockdown mice had an increased susceptibility to Salmonella infection as compared with single PGLYRP2−/− knockdown mice [46], which indicate that PGLYRP2 plays a protective role in the control of S. enterica serovar Typhimurium infection in vivo through NOD2-dependent mechanism. The gene discussed is NOD2; the disease is Salmonella Infections.