Upon examining the brains of mice at baseline (4 dpi) and following infection (8 dpi), we observed no differences at baseline between WT and STING-/- mice, however the total CD4+ T cells and the CD4/CD8 ratio was significantly decreased in STING-/- mice, suggesting that there is a defective recruitment or maintenance of T cells in the brain (Fig 6). The gene discussed is CD8A; the disease is infection.