We tested the Idylla NRAS-BRAF-EGFR S492R Mutation Assay cartridges, originally designed for colorectal cancer, but also of interest for melanoma as it enables, in a single 2-hour run without any sample pre-treatment, the qualitative detection of 5 mutations in codon 600 of the BRAF gene, 18 mutations in codons 12, 13, 59, 61, 117 and 146 of the NRAS gene and 2 mutations in codon 492 of the EGFR gene. Here, NRAS is linked to colorectal cancer.