PTPRC and infection: In order to explore IL-11 production in these cell types, we sorted epithelial cells (CD45-/Ly6G-/EpCam+), neutrophils (CD45+/Ly6G+/EpCam-), and non-neutrophil leukocytes (CD45+/Ly6G-/EpCam-) from lung single-cell suspensions generated from mice treated with saline or E. coli. When normalized to values collected from uninfected lung homogenates, IL-11 transcription was significantly higher in epithelial cells compared to neutrophils and other leukocytes, regardless of infection (Fig 2A).