MaxiK+ channels in RPE control the changes in intracellular Ca2+, in turn regulating several cell functions including dark adaptation of photoreceptor activity, differentiation and vascular endothelial growth factor (VEGF) secretion [54, 55], thereby suggesting possible involvement of KCNMA1 in myopia-related pathologic changes, such as the initiation of choroidal neovascularization and changes in the blood-retinal barrier [56]. The gene discussed is VEGFA; the disease is myopia.