The effect of GLIS3 mutations on glucose metabolism was further explored and in patients with T2D, levels of HbA1c were nominally elevated to 7.20% (SD:1.69) among carriers of rare GLIS3 variants compared to 6.80% (SD:1.23) among non-carriers, p = 0.02 (Table 3). The gene discussed is GLIS3; the disease is type 2 diabetes mellitus.