GLIS3 and type 2 diabetes mellitus: Thus, the prevalence of rare GLIS3 variants was 2.4% among patients with T2D compared to 1.7% among non-diabetic individuals revealing a slight enrichment of rare GLIS3 variants in patients having T2D with odds ratio (OR) of 1.37 (IQR: 1.01–1.85, p = 0.04, Table 2).