EGFR and lung adenocarcinoma: DWI parameters, minimum ADC and normalized ADC ratio, for the solid BM was reported to predict the EGFR mutation status in BM from lung adenocarcinoma,[14] and minimum ADC and ADC transition coefficient (ATC, ADC changes at the brain-metastasis interface) as predictor for OS.[15] We found that the high prevalence of intratumoral hemorrhage or necrosis in BM is a major technical issue, and small BM was only detected on 3D T1 imaging and too small to be measured on ADC map.