C3 and infection: The identification of CSF1R+ macrophages/monocytes as a local source of C3 during infection (Figure 4D) is also critical, as these cells are recruited to the cornea in the early stages of HSV-1 infection and are associated with corneal nerve damage in HSV-1 keratitis (Chucair-Elliott et al., 2017b; Conrady et al., 2013).