APC and infection: We showed that in response to infection with the TT‐producing Salmonella, APC‐deficient or haploinsufficient cells present (a) a sustained DDR response (Figures 2, 7, and S4), (b) a reduced capacity to repair DNA damage in response to a broad panel of genotoxic agents (Figures 3 and S4), and (c) a failure to induce upregulation of the cyclin kinase inhibitor p21 and consequently to activate a proper cell cycle arrest leading to proliferation in spite of the presence of DNA damage (Figures 4, 5, and 8).