Salmonella infection is associated with the activation of the PI3K/AKT axis (Steele‐Mortimer et al., 2000); however, in our experimental set‐up, the ability to inhibit the checkpoint responses and maintain Ki67 expression was predominantly observed in cells infected with the genotoxic strain compared with the effect induced by the control strain MC1 ΔcdtB (Figures 4a and 8b), which is consistent with activation of PI3K and AKT observed in response to CDT or ionising radiation (Frisan, Cortes‐Bratti, Chaves‐Olarte, Stenerlow, & Thelestam, 2003; Seiwert et al., 2017). Here, AKT1 is linked to Salmonella Infections.