APC and infection: To address this issue, we have assessed the consequences of infection with Salmonella enterica, the only genotoxin‐producing bacterium associated with an increased risk of developing hepatobiliary and colon carcinoma in humans (Dutta, Garg, Kumar, & Tandon, 2000; Mughini‐Gras et al., 2018) on alteration of the DDR and acquisition of genomic instability in normal and APC‐deficient cells, using classical two‐dimensional (2D) and organotypic three‐dimensional (3D) tissue models.