To assess whether these pathways contribute to inhibit the checkpoint response upon MC1 TT infection in APC‐deficient cells, leading to accumulation of genomic instability, 1CTA cells were preincubated with the inhibitors GDC‐0941 (1 μM) and SB203580 (10 μM) specific for PI3K and MAPK p38, respectively, prior infection. The gene discussed is APC; the disease is infection.