Finally, we examined the breast and liver cancer survival statistics in the TCGA and we found that patients with low SRF expression have a poor prognosis for overall survival (Breast HR = 0.8 (0.72–0.89) Logrank P = 5e−5; HCC HR = 0.67 (0.47–0.96) Logrank P = 0.027; Fig 6D). Here, SRF is linked to hepatocellular carcinoma.