However, analyses ofCD8+ T cell subsets of naive cells (CD62L+CD44-), central memory cells(CD62L+CD44+), and effectors (CD62L-CD44+) revealed that rhCypA inducedenhanced accumulation (by 65% as compared to the placebo control) of effectorcytotoxic T cells on day 9 post-transplantation of EL-4 tumor cells (data arenot shown, Fig. 3).These data correlated well with the tumorrejection dynamics under rhCypA treatment(Fig. 1). This evidence concerns the gene CD44 and neoplasm.