Some scientists reported that five members of miR-15 family, which included miR-15a, miR-15b, miR-16, miR-195 and miR-503, activated T cell response by inhibiting the function of MDSCs and/or Tregs in the tumor microenvironment through blocking PD-L1/PD-1 signaling pathway 42, 45, 49, 50, however, miR-424(322), another member of miR-15 family was inversely correlated with PD-L1 pathways. The gene discussed is CD274; the disease is neoplasm.