Our study has demonstrated that SR-B1 protein not only was high expressed in 18/26 (69.2%) liposarcoma, but also was low expressed in 1/20 (5.00%) rhabdomyosarcoma, 2/43 (4.70%) leiomyosarcoma and 1/18 (5.55%) Ewing's sarcoma. The gene discussed is SCARB1; the disease is leiomyosarcoma.