As shown in Figure 3C, by using TIMER, a positive correlation was observed between BOLA2 mRNA expression and defined reactive oxygen species (ROS) modulator genes in HCC, such as p62, autophagy-related 4B (ATG4B) and Kelch-like ECH-associated protein 1 (Keap1), whereas BOLA2 mRNA expression was inversely correlated with nuclear factor erythroid 2-related factor 2 (NRF2). The gene discussed is KEAP1; the disease is hepatocellular carcinoma.