BOLA2 expression is regulated by at least four mechanisms: (i) specific in-frame fusion transcript regulation, which controls the copy number; (ii) monothiol CGFS glutaredoxin binding partners 28; (iii) a glutaredoxin-3 (GRX3)-dependent anamorsin maturation pathway 29; and (iv) as a c-Myc-targeted gene in HCC 10. This evidence concerns the gene BOLA2 and hepatocellular carcinoma.