The expression levels of ACTN1, ACTN2 and ACTN3 (high vs. low), age (≥60 vs. <60 years), WBC count (≥15 vs. <15×109/L), FLT3-ITD (positive vs. negative) and other common AML mutations with relatively high frequency in this study (NPM1, DNMT3A, IDH1/2, RUNX1, TET2 and NRAS/KRAS; mutated vs. wild type), were selected to construct the Cox regression model (Table 3). The gene discussed is ACTN3; the disease is acute myeloid leukemia.