Multivariate Cox proportional regression analysis revealed that NRBP1 expression (P = 0.014), age (P = 0.021), tumor grade (P = 0.011), and lymph node metastasis (P = 0.006) are independent prognostic factors for the overall survival of BCa patients (Table 2). This evidence concerns the gene NRBP1 and metastatic malignant neoplasm in the lymph nodes.