Multivariate analysis showed that tumor multiplicity (p = 0.036) and tumor size (p = 0.001) were independent risk factors for OS in female patients, whereas HBV-DNA level (p = 0.016), tumor multiplicity (p = 0.008), tumor size (p < 0.0001), HGB level (p = 0.001), TBIL level (p = 0.023), and AFP level (p < 0.0001) were independent risk factors for OS in male patients (Table 4). This evidence concerns the gene CYGB and neoplasm.