Our data showed that VP significantly downregulated the expression of PD-L1 in HNSCC cells, consistent with the results of Hsu et al. who reported that PD-L1 expression was correlated with YAP expression and VP downregulated PD-L1 expression in human malignant pleural mesothelioma 51. The gene discussed is CD274; the disease is malignant pleural mesothelioma.