Currently, there are some reported signaling pathways that may be associated with bone metastasis of prostate cancer, such as mesenchymal to epithelial transition factor pathway, vascular endothelial growth factor pathway, β2-adrenergic receptor pathway, androgen receptor pathway, and RANK/RANKL/OPG signaling pathway 13-17. The gene discussed is TNFSF11; the disease is prostate cancer.