This study explored the potential molecular mechanism of circMYLK in HCC, and our results demonstrated that circMYLK could alleviate the inhibition of miR-362-3p on Rab23 expression by targeting miR-362-3p, thus promoting the occurrence and development of HCC, which provide a new direction and theoretical basis for the early diagnosis and treatment of liver cancer. Here, RAB23 is linked to liver cancer.