In a multivariable analysis, CEA (HR: 1.01, 95% CI: 1.00–1.01), tumor size (HR: 1.19, 95% CI: 1.02–1.40) and venous (HR: 5.55, 95% CI: 2.04–15.06) and perineural invasion (HR: 2.34, 95% CI: 1.03–5.29) remained independent and significant factors affecting CSS (Table 3). This evidence concerns the gene CEACAM5 and neoplasm.