MKI67 and neoplasm: Tumour cell proliferation, as measured by the Ki67 labelling index, was significantly reduced after BTZ+TMZ 164 mg/m2 treatment compared with TMZ 164 mg/m2 (P < 0.05), BTZ+TMZ 82 mg/m2 (P < 0.001), BTZ monotherapy (P < 0.01) and vehicle control (P < 0.05, one-way ANOVA, Fig. 4b, d).