Collectively, our findings indicate that emergence from metastatic dormancy and subsequent disease recurrence reflects a phenotypic shift from a Pfkfb3LowAutophagyHigh to a Pfkfb3HighAutophagyLow profile, suggesting that monitoring tumor Pfkfb3 and autophagy status may offer insights into patient long-term survival and response to therapy. This evidence concerns the gene PFKFB3 and neoplasm.