However, Brn-3b promotes cell proliferation/growth in other cells by activating cell cycle genes, cyclin D1/CDK434–37 but can confer drug resistance and migratory potential to cancer cells by activating the small heat shock protein, HSP27 and/or repressing adhesion molecule plakoglobin (γ-catenin)38,39. This evidence concerns the gene POU4F2 and cancer.