This is carried out by activating AMPK signaling and causing cell cycle arrest [107]; Baicalin prevented the development of cardiac fibrosis, mediated by AngII, by activating AMPK/TGF-β/Smads signaling pathway [108]; restoration of AMPK activity during AngII-induced hypertension ameliorates vascular function which was related to inhibition of NADPH-oxidase and xanthine oxidase activity. This evidence concerns the gene PRKAA1 and Hypertension.