MTM1 and X-linked myotubular myopathy: DNM2 levels are increased in XLMTM, and when its levels are reduced in Mtm1 KO mice, either through germline Dnm2 mutation or by using antisense oligonucleotides, most aspects of the Mtm1 KO disease phenotype improve (Cowling et al., 2014; Tasfaout et al., 2018).