INPP5B and oculocerebrorenal syndrome: A transgenic Ocrly/−;Inpp5b−/− double KO mouse expressing human INPP5B was developed as a model of Lowe syndrome and Dent disease (Bothwell et al., 2011) and was used to confirm accumulated PtdIns(4,5)P2 in endolysosomes, hyper-polymerization of F-actin and impaired receptor trafficking (Festa et al., 2018).