Lastly, mutations in two genes called protrudin (ZFYVE27) and spastizin (ZFYVE26), which encode FYVE domain-containing proteins, cause subtypes of spastic paraplegia (MIM 610244 and MIM 270700, respectively) (Mannan et al., 2006; Hanein et al., 2008). Here, ZFYVE26 is linked to Spastic paraplegia.