BIN1 and centronuclear myopathy: For example, dominant mutations in dynamin 2 (DNM2) and recessive mutations in bridging integrator 1 (BIN1) are associated with CNM (Bitoun et al., 2005; Nicot et al., 2007); both proteins physically interact, both have PtdIns(4,5)P2-binding motifs, and mutations in both alter their PIP binding (Zhao et al., 2018).