INPP5E and Joubert syndrome: Mutations in INPP5E, which encodes a PtdIns(4,5)P2 and PtdIns(3,4,5)P3 5-phosphatase, can cause Joubert syndrome (MIM 213300) and MORM syndrome (which stands for mental retardation, truncal obesity, retinal dystrophy and micropenis; MIM 610156) (Bielas et al., 2009; Jacoby et al., 2009).