Overexpressed EPHA2 promotes tumor cell proliferation, migration, invasion, and metastasis; and EPHA2 is activated through phosphorylation at serine-897 by AKT, p90 ribosomal S6 kinases, and protein kinase A, but not by EPHRIN-A1 [1–3, 18, 19]. The gene discussed is EPHA2; the disease is neoplasm.