Since M802 had a role in inhibiting proliferation and promoting apoptosis in Herceptin-sensitive (HER2-positive) tumor cells, we examined the effect of M802 and Herceptin on changes in the levels of proteins in the classical pathways downstream of HER2 that regulate cell cycle progression and/or cell death after M802 and Herceptin administration. This evidence concerns the gene ERBB2 and neoplasm.