In CD4+ T cells from SLE patients and HCs, HERV-E clone 4–1 mRNA expressions were higher when both NFAT1 was overexpressed and 5-aza C was used than that when NFAT1 was overexpressed or 5-aza C was used (Fig. 4a and b); accordingly, HERV-E clone 4–1 mRNA expressions were higher when both ER-α was overexpressed and 5-aza C was used than that when ER-α was overexpressed or 5-aza C was used (Fig. 4c and d). This evidence concerns the gene ESR1 and systemic lupus erythematosus.