Intracellular IL-17 level and IL-17 level in culture supernatants increased when CD4+ T cells of SLE were transfected with 3’LTR expression plasmids or MBD2 expression plasmids and decreased when transfected with miR-302d mimics (Fig. 5g-j). The gene discussed is CD4; the disease is systemic lupus erythematosus.