IRF9 and systemic lupus erythematosus: We also detected the expression of IRF-9 which was a proved target of miR-302d in SLE [21] and found that overexpression of 3’LTR of HERV-E clone 4–1 increased the protein levels of IRF9 and miR-302d mimics could rescue the increase of IRF9 protein by the 3’LTR (Fig. 5e).