He was diagnosed as SLE in local hospital for facial maculopapulae, arthritis, pericardial effusion, hemolytic anemia and severe thrombocytopenia, accompanying with high titers of antinuclear antibody (ANA), anticardiolipin antibody (ACL), as well as decreased complements, according to the Systemic Lupus International Collaborating Clinics (SLICC) criteria [5]. The gene discussed is ACLY; the disease is pericardial effusion.