Increasing evidence suggests that HIIT can improve post-infarction left ventricular remodeling [40], augment stroke volume in patients with type 2 diabetes [41], optimize heart rate recovery after exercise in MI patients [42], and improve brachial artery flow-mediated dilation in sedentary adults [43] and type 2 diabetes [44, 45], which together may contribute to the improvements in insulin sensitivity, blood pressure, and body composition [46]. The gene discussed is INS; the disease is infarction.