NLRP3 and cancer: Since targeting the NLRP3 inflammasome pathway has been suggested to be a potential strategy for cancer immunotherapy [3, 10, 11, 14], gene expression of related targets in the NLRP3 cascade was detected by real-time PCR to clarify the mechanisms underlying this signaling pathway in MDA-MB-231 cells after treatment with BBR (0, 10, 20, 400 μg/ml) for 48 h.