Importantly, in addition to head- and -neck, CASC9 was also upregulated in squamous cell carcinomas from cervix and the lung, suggesting that strong CASC9 overexpression may be especially associated with aberrant squamous differentiation and may be valuable as a biomarker for cancer detection, but especially for squamous carcinomas. The gene discussed is CASC9; the disease is squamous cell carcinoma.