CD4 and infection: It is therefore perhaps not surprising that a low EOT CD4 count was not associated with an increased risk of infection, which means that a CD4 cell count is not useful to manage anti-viral or microbial prophylaxes, in clinical practice (the 200/mm3 threshold for discontinuing prophylactic measures was first suggested by HIV-treating physicians, but has never been validated in onco-heamatology patients [22, 23]).