Due to the small number of patients with secondary cancers as the first event (n = 10), we could not investigate the association of EOT CD4, CD8 and NK cell counts with the incidence of those events; nevertheless, of these 10 patients, 4 had EOT CD4 > 200/mm3, 4 had EOT NK > 100/mm3 and 5 had EOT CD8 > 150/mm3, a proportion rather similar to that measured in the entire cohort. The gene discussed is CD4; the disease is cancer.