It would be interesting to further investigate CD4 effects in CLL, and to observe whether patients with low EOT CD4 already presented with low CD4 prior to FCR treatment; this could help clinicians identify patients with a high probability of reaching low EOT CD4 after CIT, and thus help select patients who would benefit the most from CIT, which would be a useful distinction to make as FCR is currently being compromised by other first-line therapeutic strategies [39]. The gene discussed is CD4; the disease is B-cell chronic lymphocytic leukemia.