Moreover, large scale RNA interference screen for suppressors of AML1-ETO in vivo showed that calpainB is required for AML1-ETO-induced leukemia in Drosophila. Surprisingly, calpainB inhibition in Kasumi-1 cells (AML patient cell line carrying t(8;21) translocation) leads to AML1-ETO degradation and impairs their clonogenic potential [263]. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.