More recently, Al-Disi et al. [45] demonstrated that a high-fat diet (75 g of fat per m2 body surface) exacerbated the postprandial endotoxemia in normal-weight and T2DM participants, but with a different impact on cardio-metabolic health: non-diabetic subjects appeared to have better metabolic resistance to the insult of a high-fat diet as seen by a postprandial increase in triglycerides and insulin and a decrease in HDL and LDL cholesterol [45]. Here, INS is linked to serum lipopolysaccharide activity.