In a model of lung cancer, Hartwig et al. determined that the cytokine secretion of TRAIL-resistant cancer cells on TRAIL stimulation is dependent on FADD and leads to the polarization of monocytes to MDSCs (myeloid-derived suppressor cells) and M(IL-4)-like macrophages dependent on CCL2 (chemokine (C-C motif) ligand 2) [94]. The gene discussed is TNFSF10; the disease is lung cancer.