TRAIL-induced NF-kB activation also results in the release of proinflammatory cytokines by pancreatic cancer cell lines, including interleukin (IL)-8, monocyte chemoattractant protein 1 (MCP1), and the urokinase-type plasminogen activator (uPA) [32]. This evidence concerns the gene TNFSF10 and pancreatic neoplasm.