LRP6 and familial pancreatic carcinoma: In fact, treatment of pancreatic cancer cells with calcipotriol induces the expression of low-density lipoprotein receptor adaptor protein 1 (LDLRAP1), which interacts with tyrosine motifs of the LRP6 cytoplasmic tail, thereby inducing LRP6 clathrin-dependent endocytosis and subsequent lysosome-dependent degradation.