SST2 and SST5 (with the latter more expressed than SST2) were the prevalent subtype expressed in GH-secreting pituitary adenoma cells, and the treatment of primary cultures with 100 nM OCT and PAS at different time-points (4 and 24 h) demonstrated superimposable effects of the two drugs in reducing GH secretion. This evidence concerns the gene PLXNA2 and pituitary gland adenoma.