An average of 53.8% (range 22.3−86.6%) of ALK+ tumor cells, 6% (range 3.5−9.5%) of ALK− tumor cells, 6.8% (range 2.1−11.1%) of adjacent non-tumor cells in ALK+ specimens, and 5.3% (range 0.7−11.2%) of adjacent non-tumor cells in ALK− specimens exhibited positive ALK FISH signal patterns. This evidence concerns the gene ALK and neoplasm.