TARDBP and amyotrophic lateral sclerosis: ALS can be divided into (a) familiar, characterized by the presence of inherited mutations in one of the following genes that are causative of this disease: superoxide dismutase 1 (SOD1), VCP, TAR DNA binding protein 43 (TDP-43), ubiquilin 2, C9orf72, and profiling, and (b) sporadic, which account for the 90–95% of the cases [107].