Take home message: Mitochondrial DNA variants in ND1 and ND5 genes (coding NADH dehydrogenase subunit 1 and 5 of complex I) might affect the oxidative phosphorylation function of complex I and are associated with the risk of drug-induced liver injury (DILI) due to anti-TB drugs, especially isoniazid. Here, MT-ND5 is linked to tuberculosis.